Mechanisms, effects of drugs action and drugs interactions in human

Timetable

Module aim (aims)

The aim of the module is to:
introduce to discovering and steps of production of brand-name drugs (original drugs)
present the knowledge about similarities and differences between synthetic brand-name drugs and generic drugs
introduce to biopharmaceutics ( biological drugs) and biosimilar drugs– production, contribution to pharmaceutical market, immunogenicity
develop the knowledge about the mechanisms of drug metabolism and interactions of drugs with other drugs or diet
develop the knowledge about compartments and the mechanisms of drugs action in human cells
introduce to drug affinity to the cellular targets (enhancement with using biotechnology, nanotechnology)
indicate the problem with human cells resistance to drugs (chemoresistance, multidrug resistance proteins)
show the newest therapies used in treatment of tumors, cardiovascular, neurodegenerative diseases
introduce to immunotherapy of tumors as one of the "hot topics" in biological and medical studies (e.g. immunotherapy with check points inhibitors)
develop students awareness of challenges in contemporary medicine and develop curiosity about looking for the newest therapies approved by FDA and EMA and trends in biological and medical studies

Pre-requisites in terms of knowledge, skills and social competences (where relevant)

General knowledge about human cell`s biology

Syllabus

Discovering and production of brand-name drugs (original drugs) – pre-clinical studies, clinical trials, drug patent and its expiration, serendipity in drug discovery, personalised medicine
Synthetic brand-name drugs and generic drugs - similarities and differences
Biopharmaceutics ( biological drugs) and biosimilar drugs – production, contribution to pharmaceutical market, immunogenicity
Drug metabolism and interactions of drugs with other drugs or diet ingredients (poor, intermediate, ultrafast metabolizers)
Main cellular targets of drugs, diversity of drug action mechanisms and enhancement of drug affinity (monoclonal antibodies, liposomes, molecular Troian horse strategy)
Multidrug resistance phenomenon in human cells (chemoresistance, MDR proteins)
Th newest therapies used in treatment of tumors, cardiovascular, neurodegenerative diseases (FDA/EMA approved)
Trends in biological and medical studies focused on new potential drugs (combination therapies, micro and circRNA studies)
Learning Outcomes. Student will be able to:
mention and characterise discovering and production process of brand-name drugs (original drugs )
explain similarities, differences between brand-name and generic drugs
characterise biopharmaceutics and biosimilar drugs (with regard to their production, biological features, immunogenicity) and give examples of these drugs
recognise the effect of genes to drug metabolism (poor/intermediate/ultrafast metabolisers) and explain interactions between drugs/diet ingredients
indicate main targets for drugs in human cells and describe diversity of drugs action mechanisms
explain the influence of MDR proteins to multidrug resistance phenomenon and indicate contribution of biotechnology, nanotechnology in enhancement of drug affinity to human cells
give examples of the newest therapies used in treatment of tumors, cardiovascular, neurodegenerative diseases, indicate trends in biological and medical studies, but also suggest their new directions
develop own awareness of challenges in contemporary medicine and develop own curiosity about trends in biological and medical studies

Reading list

original scientific article, reviews, data from bachelor and master thesis available at the lecturer