|Module title||Principles of medical virology|
|Module lecturer||prof. UAM dr hab. Julia Durzyńska, prof. UAM dr hab. Robert Nawrot, dr hab. Justyna Broniarczyk|
|Lecturer position||profesor uczelni|
|Faculty||Faculty of Biology|
Module aim (aims)
• To familiarize the students with the properties of virus particles and structure and complexity of virus genomes.• To familiarize with viral pathogenesis, virus-related diseases and patterns of infection.• To explain virus transformation and oncogenesis.• To familiarize with pathology of prion diseases.• To familiarize with prevention and therapy of virus infection.• To discuss the future viral therapies, benefits, hopes and threats in biotechnology and medicine.• To familiarize students with safety rules in laboratory of virology.
Pre-requisites in terms of knowledge, skills and social competences (where relevant)
The students should be familiar with the structure and biochemistry of prokaryotic and eukaryotic cells.
Lectures:Week 1: The properties of virus particles (capsid symmetry and virus architecture, virus receptors, recognition and binding).Week 2: The structure and complexity of virus genomes (replication strategies, expression processing of viral or cellular pre-mRNA, RNA interference, epigenetics, the diversity of viral translation strategies, packing of the viral genome, virion maturation, release and spread of virion).Week 3: Virus-related diseases. Viral pathogenesis (infection of populations, viral virulence, cellular defenses, viruses and apoptosis).Week 4: Patterns of infection (acute infections, persistent infections, latent infections, abortive infections, transforming infections).Week 5: Transformation and oncogenesis.Week 6: Prevention and therapy of virus infection. Pathology of prion diseases.Week 7: Viruses and the future (new and emergent viruses, zoonoses, bioterrorism, virotherapy, viruses for gene delivery, viruses and nanotechnology, viruses and biosphere). Laboratories:Week 1: Identification of HPV viruses DNA using PCR method.Week 2: Detection of Epstein-Barr virus using the ELISA assay. Biosafety levels in virology labs.Week 3: Pseudovirus (PsV) technology as a tool to monitor HPV infection in different cell lines.
1. Fields BN et al.: Fundamental Virology, Lippincott-Raven, Philadelphia-Nwe York, 19952. Dimmock NJ, Primrose SB.: Introduction to Modern Virology, Blackwell Science, Oxford, 19983. Cann AJ: Principles of Molecular Virology, Elsevier, Amsterdam-Boston-London, 20124. Flint SJ et al.: Principles of Virology, ASM Press, Washington, 2009