General information

Module title Regulation of gene expression by RNA
Language English
Module lecturer dr Maciej Szymański
Lecturer's email mszyman@amu.edu.pl
Lecturer position adiunkt
Faculty Faculty of Biology
Semester 2021/2022 (winter)
Duration 30
ECTS 4
USOS code 01-RGERNA-PIE

Timetable

Module aim (aims)

Demonstration of the regulatory mechanisms of gene expression involving noncoding RNAs and their role in the organisms' development and response to changing environmental conditions. Demonstration of practical applications of RNA technologies in basic research, medicine and biotechnology

Pre-requisites in terms of knowledge, skills and social competences (where relevant)

Basics of molecular biology

Syllabus

Week 1 What do RNAs do in the cell? Housekeeping and regulatory RNAs. Week 2 RNA regulation in bacteria – stress response and environmental adaptation Week 3 Riboswitches – turning genes on and off by changing the RNA structure Week 4 Seminar Week 5-6 Epigentics – the role of non-coding RNAs in setting up the epigentic features and chromatin remodelling Week 7 Controlling transcription – RNA modulators of the activity of transcription factors nad RNA polymerases Week 8 Post-transcriptional regulation – RNAs affecting splicing, translation and stability of mRNA Week 9 RNA editing and RNA modifications as regulatory mechanisms Week 10 Seminar Week 11 Non-coding RNAs in viruses Week 12 Non-coding RNAs in human diseases and congenital disorders – from diagnostic markers to therapeutic targets Week 13 Artificial RNA regulators – RNA-based strategies for controlling gene expression and their applications in research, biotechnology and medicine Week 14 The expanding universe of noncoding RNAs – the progress and the challenges of RNomics Week 15 Seminar

Reading list